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Cat. No.	Product Name	Target	Signaling Pathways
T12774	RSV-IN-1	RSV	Microbiology/Virology
	RSV-IN-1 是一种有效的人呼吸道合胞病毒的抑制剂，IC50为 0.11 μM。
T61343	RSV/IAV-IN-1
	RSV/IAV-IN-1 (compound 14e) 是一种有效的 RSV/IAV 双重抑制剂。RSV/IAV-IN-1 的细胞毒性低于临床药物利巴韦林。RSV/IAV-IN-1 具有研究 RSV 和/或 IAV 感染的潜力。
T79219	RSV L-protein-IN-3	RSV	Microbiology/Virology
	RSVL-protein-IN-3为一野生型RSV聚合酶抑制剂，具IC50值10.4 μM及EC50值2.1 μM(RSV)。相较之下，RSV/IAV-IN-2之细胞毒性显著低于临床活性分子Ribavirin。
T61217	RSV-IN-3
	RSV-IN-3 (Compound 1) 是呼吸道合胞病毒 (RSV) 和流感病毒 A (IAV) 的双重抑制剂。RSV-IN-3 具有抗 RSV 活性 (EC50=32.70 μM)。
T61704	RSV-IN-6
	RSV-IN-6 (Compound 53) is a specific agent that effectively inhibits the respiratory syncytial virus (RSV) by targeting the M2-1 protein. It shows strong potency, with EC50 values of 4.4 μM and 1.3 μM against RSV-A and RSV-B strains, respectively [1].
T61291	RSV/IAV-IN-2
	RSV/IAV-IN-2 (compound 14c) 是一种有效的 RSV/IAV 双重抑制剂。RSV/IAV-IN-2 的细胞毒性低于临床药物利巴韦林。RSV/IAV-IN-2 具有研究 RSV 和/或 IAV 感染的潜力。
T79220	RSV L-protein-IN-4	RSV	Microbiology/Virology
	RSVL-Protein-IN-4 (Compound C)为非竞争性RSV聚合酶抑制剂，IC50为0.88 μM。该化合物对RSV株显示出抗病毒活性，其EC50为0.25 μM。
T73370	RSV-IN-7
	RSV-IN-7 (example 253) 是一种 RSV 抑制剂 (EC50: < 0.4 μΜ)。
T60910	RSV-IN-4
	RSV-IN-4 (Compound 2) 具有抗 RSV 活性，EC50值为11.76 μM。RSV-IN-4 是呼吸道合胞病毒 (RSV) 和甲流病毒 A (IAV) 的双重抑制剂。
T77027	Gontivimab
	Gontivimab (ALX-0171; VR-465) 是一种有效的抗RSV 预融合 F 蛋白纳米抗体，KD 值为 0.113 nM。Gontivimab 显示出抗病毒活性。Gontivimab 可降低鼻腔和肺部的RSV 负荷。
T76752	Motavizumab
	Motavizumab (MEDI-524)为针对humanRSV(呼吸道合胞病毒)的单克隆抗体。该化合物主要应用于对高危婴儿的呼吸道合胞病毒感染的研究。
T79221	RSV L-protein-IN-5	RSV	Microbiology/Virology
	RSVL-protein-IN-5（compound E）是一种高效针对呼吸道合胞病毒（RSV）的抑制剂，拥有EC50值为0.1 μM。该化合物在IC50为0.66 μM的条件下能够抑制聚合酶（Polymerase），并通过阻断病毒转录物的鸟苷酸化过程来抑止RSVmRNA的合成。RSVL-protein-IN-5具有中等细胞毒性（CC50为10.7 μM，HEp-2细胞），同时，在每日4.1 mg/kg剂量下，能减少RSV感染小鼠模型中的病毒滴度。
T79217	RSV L-protein-IN-2	RSV	Microbiology/Virology
	RSVL-protein-IN-2 (Compound A)为一种RSV聚合酶的非竞争性抑制剂，其IC50值为4.5 μM。此化合物对长RSV株表现出抗病毒活性，EC50值达1.3 μM。
T36440	GS-441524 tris-isobutyryl ester
	GS-441524tris-isobutyryl ester is a prodrug form of the antiviral nucleoside analog and remdesivir metabolite GS-441524 .1It reduces the cytopathic effect of respiratory syncytial virus (RSV) in infected HEp-2 cells with an EC50value of 0.26 μM. 1.Mackman, R.L., Hui, H.C., Perron, M., et al.Prodrugs of a 1’-CN-4-aza-7,9-dideazaadenosine C-nucleoside leading to the discovery of remdesivir (GS-5734) as a potent inhibitor of respiratory syncytial virus with efficacy in the african green monkey mode...
T37295	Ganglioside GM1 Asialo Mixture
	Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na...
T69014	Sekikaic Acid
	Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities. It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM. Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 µg/ml). It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 µM).
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

化合物

Cat.No: T12774

Target: RSV

Cat.No: T61343

RSV L-protein-IN-3

Cat.No: T79219

Target: RSV

Cat.No: T61217

Cat.No: T61704

Cat.No: T61291

RSV L-protein-IN-4

Cat.No: T79220

Target: RSV

Cat.No: T73370

Cat.No: T60910

Cat.No: T77027

Cat.No: T76752

RSV L-protein-IN-5

Cat.No: T79221

Target: RSV

RSV L-protein-IN-2

Cat.No: T79217

Target: RSV

GS-441524 tris-isobutyryl ester

Cat.No: T36440

Ganglioside GM1 Asialo Mixture

Cat.No: T37295

Cat.No: T69014

Cat.No: T38297

Synonym: Ribavirin-13C5

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